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doi: 10.3389/fendo.2023.1198475 45 YuanYSzetoIMLiNYangHZhouYLiuBet al

Trials 21, 162

Natural polyphenols like castalagin (145) and cranberry proanthocyanidins (146) act as prebiotics, reshaping gut microbiota to alter BA profiles (e.g., increasing taurine-conjugated BAs or reducing local BA accumulation, respectively) and exert anti-tumor effects or enhance ICI responsiveness